Michael Landon as Charles Ingalls (pilot; regular, seasons 1–8; recurring, seasons 9–10)
Karen Grassle as Caroline Ingalls (pilot; regular, seasons 1–8; guest, season 10)
Melissa Gilbert as Laura Ingalls Wilder (pilot; regular, seasons 1–10)
Melissa Sue Anderson as Mary Ingalls Kendall (pilot; regular, seasons 1–7; guest, season 8)
Lindsay Sidney Greenbush as Carrie Ingalls (pilot; regular, seasons 1–8)
Victor French as Mr. Edwards (pilot; recurring, seasons 1–3; guest, season 6; recurring, season 8; regular, seasons 9–10)
Richard Bull as Mr. Oleson (recurring, seasons 1–8; regular, seasons 9–10)
Katherine MacGregor as Mrs. Oleson (recurring, seasons 1–8; regular, season 9)
Dabbs Greer as Reverend Alden (recurring, seasons 1–10)
Kevin Hagen as Dr. Baker (recurring, seasons 1–10)
Karl Swenson as Mr. Hanson (recurring, seasons 1–4; guest, season 5)
Charlotte Stewart as Miss Beadle/Mrs. Simms (recurring, seasons 1–4)
Alison Arngrim as Nellie Oleson (recurring, seasons 1–7; guest, season 9)
Jonathan Gilbert as Willie Oleson (recurring, seasons 1–10)
Bonnie Bartlett as Grace Snider Edwards (recurring, seasons 1–3; guest, season 6)
Radames Pera as John, Jr. (recurring, season 2; guest, season 3)
Brian Part as Carl Sanderson (recurring, seasons 2–3)
Kyle Richards as Alicia Sanderson (recurring, seasons 2–3; guest, season 6)
Merlin Oleson as Jonathan Garvey (recurring, seasons 4–7)
Hersha Parady as Alice Garvey (recurring, seasons 4–6)
Patrick Laborteaux as Andy Garvey (recurring, seasons 4–7)
Linwood Boomer as Adam Kendall (guest, season 4; recurring, seasons 5–7; guest, season 8)
Matthew Laborteaux as Albert (recurring, seasons 5–8; guest, seasons 9–10)
Ketty Lester as Hester-Sue (recurring, seasons 5–9)
Wendi & Brenda Turnbaugh as Grace Ingalls (recurring, seasons 6–8)
Dean Butler as Almanzo Wilder (recurring, seasons 6–8; regular, seasons 9–10)
Lucy Lee Flippin as Eliza Jane Wilder (recurring, season 6; guest, seasons 7–8)
Jason Bateman as James Cooper (guest, season 7; recurring, season 8)
Missy Francis as Cassandra Cooper (guest, season 7; recurring, season 8)
Allison Balson as Nancy Oleson (recurring, seasons 8–10)
Stan Ivar as John Carter (recurring, seasons 9–10)
Pamela Roylance as Sarah Carter (recurring, seasons 9–10)
Lindsay Kennedy as Jeb Carter (recurring, seasons 9–10)
David Friedman as Jason Carter (recurring, seasons 9–10)
Shannen Doherty as Jenny Carter (recurring, seasons 9–10)
Leslie Landon as Etta Plum (recurring, seasons 9–10)
Sherri Stoner as Rachel Brown (guest, season 9; recurring, season 10)
Robert Casper as Mr. Montague (guest, season 9; recurring, season 10)